Severe burns in a vehicle fire are commonly associated with which combination of complications?

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Severe burns disrupt the skin barrier and trigger massive fluid and electrolyte shifts. Plasma leaks into damaged tissue (third spacing), causing hypovolemia that can lead to burn shock if fluids aren’t adequately replenished. The burned surface also drives large insensible water losses, contributing to dehydration. Wound contamination and the body’s impaired defenses raise the risk of infection, which can progress to sepsis and further destabilize circulation and metabolism. Electrolyte disturbances accompany these changes due to loss of fluids and tissue injury, with shifts in potassium and other ions common as the patient moves through resuscitation and healing. This combination—hypovolemia, water loss, electrolyte imbalance, and sepsis risk—captures the typical systemic complications of severe burns. Other options describe problems that aren’t the hallmark of extensive burn injuries.