Episodes separated in time and space due to autoimmune demyelination of the central nervous system describe which disease?

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Multiple Choice

Episodes separated in time and space due to autoimmune demyelination of the central nervous system describe which disease?

Episodes separated in time and space are characteristic of multiple sclerosis, an autoimmune attack on myelin in the central nervous system. This demyelination creates focal lesions in different CNS regions, and new lesions can appear at different times. The result is discrete neurologic events that may partially recover between attacks, giving a relapsing pattern. Symptoms vary with where the lesions occur, such as optic neuritis affecting vision, motor or sensory deficits, and coordination problems. MRI typically shows multiple lesions in various CNS white-matter areas, and CSF can show oligoclonal bands. The other conditions don’t fit this pattern: ALS involves progressive motor neuron degeneration without discrete, time-separated demyelinating episodes; Parkinson’s is a neurodegenerative movement disorder without central demyelination; myasthenia gravis is a neuromuscular junction problem with fluctuating weakness, not central demyelination.

Episodes separated in time and space are characteristic of multiple sclerosis, an autoimmune attack on myelin in the central nervous system. This demyelination creates focal lesions in different CNS regions, and new lesions can appear at different times. The result is discrete neurologic events that may partially recover between attacks, giving a relapsing pattern. Symptoms vary with where the lesions occur, such as optic neuritis affecting vision, motor or sensory deficits, and coordination problems. MRI typically shows multiple lesions in various CNS white-matter areas, and CSF can show oligoclonal bands. The other conditions don’t fit this pattern: ALS involves progressive motor neuron degeneration without discrete, time-separated demyelinating episodes; Parkinson’s is a neurodegenerative movement disorder without central demyelination; myasthenia gravis is a neuromuscular junction problem with fluctuating weakness, not central demyelination.

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